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Am J Physiol Regul Integr Comp Physiol (June 24, 2009). doi:10.1152/ajpregu.00356.2009
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297/3/R568    most recent
00356.2009v1
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Submitted on June 22, 2009
Revised on June 23, 2009
Accepted on June 23, 2009

Going with the Wnt? - Editorial Focus: Hyperaldosteronism, hypervolemia and increased blood pressure in mice expressing defective APC

Armin Just1*

1 Albert-Ludwigs-Universität Freiburg

* To whom correspondence should be addressed. E-mail: armin.just{at}physiologie.uni-freiburg.de.

Wnt signaling is classically involved in embryonic development, but also has functions in adult life in cell motility and proliferation. The canonical Wnt cascade includes the ß-catenin destruction complex with APC, Axin and GSK3, and target genes possibly including SGK1. Aldosterone regulates ENaC-dependent sodium reabsorption in the distal nephron via signal cascades involving SGK1. Bhandaru et al. in this issue of the journal explore the possibility that APC could be involved in the regulation of sodium homeostasis via SGK1.






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