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1 Biological Science Laboratories, Kao Corporation, Haga-gun, Tochigi, Japan
* To whom correspondence should be addressed. E-mail: murase.takatoshi{at}kao.co.jp.
Green tea contains a high level of polyphenolic compounds known as catechins. We investigated the effects of green tea extract (GTE), which is rich in catechins on endurance capacity, energy metabolism and fat oxidation in Balb/c mice over a 10 week period. Swimming times to exhaustion for mice fed 0.2% - 0.5% (w/w) GTE were prolonged by 8% - 24% and the effects were dose dependent, and accompanied by lower respiratory quotients and higher rates of fat oxidation, as determined by indirect calorimetry. In addition, feeding with GTE increased the level of 
-oxidation activity in skeletal muscle. Plasma lactate concentrations in mice fed GTE were significantly decreased after exercise, concomitant with increases in free fatty acid concentrations in plasma, suggesting an increased lipid utilization as an energy source in GTE -fed mice. Epigallocatechin gallate (EGCG), a major component of tea catechins, also enhanced endurance capacity, suggesting that the endurance-improving effects of GTE were mediated, at least partly, by EGCG. The -oxidation activity and the level of fatty acid translocase (FAT/CD36) mRNA in the muscle was higher in GTE-fed mice compared to control mice. These results indicate that GTE are beneficial for improving endurance capacity and support the hypothesis that the stimulation of fatty acid utilization is a promising strategy for improving endurance capacity.
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