AJP - Regulatory, Integrative and Comparative Physiology, Vol 232, Issue 5 198-R202, Copyright © 1977 by American Physiological Society
Brainstem control of shivering in the cat. II. Facilitation
L. Amini-Sereshki
Regions containing areas and pathways mediating heat gain responses in the
mesencephalon and upper pons and in the medulla were studied using topical
microinjection of a local anesthetic. These facilitatory areas and pathways
were compared in the decerebrated and intact cats. In lower pontine
preparations shivering was abolished by bilateral injections of procaine
into the lateral medullary reticular formation. Injections into the same
areas in the intact anesthetized cat resulted in the cessation of
shivering. These effects on facilitatory areas are reversible and can be
repeated in the same preparation several times. Permanent effects were
obtained by electrolytic lesions or by the local microinjections of 1%
osmic acid. In summary it shown, by means of microinjection of local
anesthetic, that the pathways mediating shivering in the intact and lower
pontine cats are located in the same area in lateral reticular formation of
pons and medulla.
