AJP - Regulatory, Integrative and Comparative Physiology, Vol 234, Issue 1 66-R71, Copyright © 1978 by American Physiological Society
Angiotensin II infusion increases vasopressin, ACTH, and 11-hydroxycorticosteroid secretion
D. J. Ramsay, L. C. Keil, M. C. Sharpe and J. Shinsako
The effects of intravenous infusion of Asp1. Ile5-angiotensin II on blood
pressure, plasma vasopressin, ACTH and 11-hydroxycorticosteroid levels and
on plasma renin activity were studied in five trained, conscious dogs. The
dogs were prepared with bilateral carotid loops. Infusion of angiotensin II
at rates of 5, 10, and 20 ng/kg.min raised its plasma concentration from 23
+/- 7 to 48 +/- 8, 125 +/- 8, and 187 +/- 21 pg/ml, respectively. The
lowest rate of infusion was mildly pressor, the two higher rates more so.
All rates of infusion promptly increased vasopressin levels and depressed
renin levels. The two higher rates also stimulated ACTH, although with a
latency of 30-45 min. Since the rates of infusion of angiotensin II
employed produced plasma levels within the physiological range, it is
suggested that peripherally generated angiotensin II may play an important
role in the regulation of vasopressin, and ACTH secretion.
