AJP - Regulatory, Integrative and Comparative Physiology, Vol 237, Issue 1 20-R25, Copyright © 1979 by American Physiological Society
Vasopressin release and drinking induced by intracranial injection of angiotensin II in monkey
G. Simonnet, F. Rodriguez, F. Fumoux, P. Czernichow and J. D. Vincent
The effects of intracerebral injection of angiotensin II (AII) on both
water intake and arginine-vasopressin (AVP) release were tested on
unanesthetized rhesus monkeys (Macaca mulatta). Injection of 10(-10) mol of
peptide was administered with a cannula microinjection system
stereotaxically implanted into different diencephalic structures. The
preoptic area, anterior part of third ventricle, caudate nucleus, and
septum appeared to be the injection sites most effective in eliciting both
drinking behavior and AVP release when the animal did not have access to
water. On the contrary, when water was presented, AVP release was blocked
after AII microinjections in the preoptic area and the third ventricle. No
drinking was observed after microinjection in the supraopticus nucleus
although AVP release was stimulated. These data suggest that AII might be
effective in the regulation of water balance by centrally controlling both
the input (drinking) and the output (ADH secretion) of water.
