AJP - Regu AJP: Renal Physiology
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Am J Physiol Regul Integr Comp Physiol 238: R438-R442, 1980;
0363-6119/80 $5.00
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AJP - Regulatory, Integrative and Comparative Physiology, Vol 238, Issue 5 438-R442, Copyright © 1980 by American Physiological Society

ARTICLES

Effect of saralasin and indomethacin on renal function in developing piglets

J. L. Osborn, J. B. Hook and M. D. Bailie

To investigate the influence of angiotensin II (AII) and renal prostaglandins on neonatal renal hemodynamics and sodium excretion, unanesthetized piglets 1-5, 18-20, and 45-50 days of age were treated with saralasin and indomethacin prior to volume expansion (VE) with isotonic saline. Saralasin did not affect basal renal blood flow (RBF) or the intrarenal distribution of blood flow as calculated as the ratio of outer-to-inner slice counts (O/I) in piglets 1-50 days of age. VE increased fractional sodium excretion equally in all animals. In 1- to 5-day-old piglets, saralasin blunted this natriuresis without affecting renal hemodynamics. Therefore, low neonatal RBF and O/I do not appear to be due to AII. In addition, indomethacin did not change renal hemodynamics in newborn piglets and did not affect the natriuresis after VE in any age group. Indomethacin decreased RBF and increased O/I of conscious 45- to 50-day-old animals. Renal prostaglandins do not appear to be a factor in control of renal hemodynamic in newborn pigs and do not influence the natriuresis in neonates following saline loading.


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K. K. Ebenezar, F. S. Ghane, and F. G. Smith
Placental-Perinatal: Effects of indomethacin on systemic and renal haemodynamics in conscious lambs
Exp Physiol, May 1, 2007; 92(3): 575 - 581.
[Abstract] [Full Text] [PDF]


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