AJP - Regulatory, Integrative and Comparative Physiology, Vol 240, Issue 1 75-R80, Copyright © 1981 by American Physiological Society
Is angiotensin essential in drinking induced by water deprivation and caval ligation?
M. C. Lee, T. N. Thrasher and D. J. Ramsay
The role of the renin-angiotensin system in drinking induced by water
deprivation and caval ligation was assessed by infusion of saralasin into
the lateral ventricles of rats. This technique was first validated by
demonstrating its capability to specifically antagonize drinking to both
systemic and central angiotensin II. However, neither the latency to drink
nor the amount of water consumed following 24- or 30-h water deprivation
was affected by saralasin. Furthermore, saralasin had no significant effect
on the recovery of blood pressure or on the water intake following ligation
of the abdominal vena cava. These observations suggest that the
renin-angiotensin system alone does not play an essential role in the
control of drinking following water deprivation or caval ligation in rats.
