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Am J Physiol Regul Integr Comp Physiol 241: R158-R162, 1981;
0363-6119/81 $5.00
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AJP - Regulatory, Integrative and Comparative Physiology, Vol 241, Issue 3 158-R162, Copyright © 1981 by American Physiological Society


ARTICLES

Electroencephalographic serotonin synchronization: area postrema and solitary tract nucleus

K. Yamasaki and M. C. Lico

Unilateral microinjection of serotonin (5-HT) into the solitary tract nucleus (STN) increased the amplitude of all electroencephalographic (EEG) waves ipsilateral to the site of injection. Unilateral STN blockage by lidocaine blocked the ipsilateral effect of 5-HT. Unilateral lesion of the area postrema (AP) increased the amplitude of the ipsilateral EEG in response to 5-HT stimulation of the obex. In contrast, unilateral lesion of both AP and STN decreased the amplitude of the ipsilateral EEG response to 5-HT. The data show that the STN is critically involved in 5-HT synchronizing mechanism and that the AP may have an inhibitory tonic effect on the STN.





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