AJP - Regulatory, Integrative and Comparative Physiology, Vol 242, Issue 1 129-R135, Copyright © 1982 by American Physiological Society

ARTICLES

Amygdaloid lesions impair ingestive responses to 2-deoxy-D-glucose but not insulin

M. G. Tordoff, P. J. Geiselman, C. V. Grijalva, S. W. Kiefer and D. Novin

Bilateral lesions of the amygdala in male rats impaired the feeding response to 2-deoxy-D-glucose (2-DG; 100, 200, and 400 mg/kg). During the first 3 h postinjection, control rats displayed a dose-related increase in both food and water consumption. Rats with amygdaloid lesions did not respond to 2-DG until the 3rd h postinjection, when only the two largest doses significantly increased food consumption. Their water intake remained unaffected throughout the 3-h postinjection period. During the 4th-24th h post-2-DG administration, both groups displayed a dose-related suppression of food and water intake. Following insulin (10 U/kg), amygdaloid and control animals were indistinguishable: both groups showed a significant short-term increase in food and water intake followed by a reduction in intakes during the 4th-24th h. Central visceral pathways that are important for the ingestive responses to 2-DG may be interrupted by amygdaloid lesions. However, pathways responsible for the ingestive behavior induced by insulin appear unaffected by damage to the amygdala.

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				B. M. King Amygdaloid lesion-induced obesity: relation to sexual behavior, olfaction, and the ventromedial hypothalamus Am J Physiol Regulatory Integrative Comp Physiol, November 1, 2006; 291(5): R1201 - R1214. [Abstract] [Full Text] [PDF]