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Am J Physiol Regul Integr Comp Physiol 242: R545-R551, 1982;
0363-6119/82 $5.00
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AJP - Regulatory, Integrative and Comparative Physiology, Vol 242, Issue 5 545-R551, Copyright © 1982 by American Physiological Society

ARTICLES

Mechanisms involved in central cardiovascular effects of prostaglandin F2 alpha

G. Feuerstein, C. J. Helke, R. L. Zerbe, D. M. Jacobowitz and I. J. Kopin

Prostaglandin F2 alpha (PGF2 alpha) injected into the cerebroventricular system (icv) of halothane-anesthetized rats increased the arterial blood pressure, heart rate, and rectal temperature. These effects were accompanied by a preferential increase in plasma norepinephrine concentration. Plasma levels of epinephrine, renin, and vasopressin were not changed in the PGF2 alpha-icv-treated rats. Bilateral vagotomy did not affect the PGF2 alpha-induced hypertension and tachycardia nor was there any change in the selective increase in plasma norepinephrine concentration. Hexamethonium pretreatment suppressed, in a dose-response manner, the increases in blood pressure, heart rate, and rectal temperature in response to PGF2 alpha-icv. Plasma norepinephrine and epinephrine levels were not altered by PGF2 alpha-icv in hexamethonium-treated rats, but plasma vasopressin concentration was markedly elevated in all hexamethonium-infused rats. These results suggest that selective central activation of the sympathetic nervous system underlies the profound cardiovascular and temperature responses elicited by central administration of PGF2 alpha.




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