AJP - Regulatory, Integrative and Comparative Physiology, Vol 243, Issue 1 131-R141, Copyright © 1982 by American Physiological Society
Hyperdynamic severe intravascular sepsis depends on fluid administration in cynomolgus monkey
G. C. Carroll and J. V. Snyder
A new model of high cardiac output septic shock in primates is presented
that includes hemodynamic and metabolic effects of separate and combined
infusions of normal saline and live Escherichia coli. In monkeys receiving
ketamine anesthesia, cardiac output (QT) increased with saline loading but
not significantly with bacterial infusion, and bacterial infusion without
saline never significantly increased QT. Depressed oxygen consumption (VO2)
was reversed with saline loading. In spite of continuing E. coli infusion,
radiolabeled microspheres showed no increase in systemic anatomic shunt
when QT was elevated. It is perceived that the tissue dysfunction
associated with sepsis, which is called septic shock, and elevation of
cardiac output are related only indirectly. High cardiac output only
reflects an adequate volume status in a stressed individual; some of the
afferent stress signals can be related to the septic state, but no specific
or direct relationship is involved. In general, shock as indicated by a
depression of VO2 does not appear to occur when QT is increased.
