AJP - Regulatory, Integrative and Comparative Physiology, Vol 244, Issue 5 611-R614, Copyright © 1983 by American Physiological Society
Suppression of afferent activity of the hepatic vagus nerve by anomers of D-glucose
A. Niijima, A. Fukuda, T. Taguchi and J. Okuda
Afferent discharges were recorded from the nerve filaments dissected from
the hepatic branch of the vagus nerve in the guinea pig. Recordings were
made in isolated and perfused liver preparations and in vivo to study the
effect of alpha and beta anomers of D-glucose on the afferent discharge
rate. Infusions of these anomers (30 mg or 50 mg dissolved in 10 ml
glucose-free Ringer solution) into the portal vein in perfused liver
preparations and intraportal injections of these anomers (50 mg/kg
dissolved in 0.2 ml saline) in vivo partially suppressed the afferent
activity. However, the effect of suppression by the beta anomer was
stronger than that of the alpha anomer. Results indicate the existence of
anomeric stereospecificity of D-glucose action to the hepatic "glucose
sensors."
