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Am J Physiol Regul Integr Comp Physiol 244: R635-R640, 1983;
0363-6119/83 $5.00
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AJP - Regulatory, Integrative and Comparative Physiology, Vol 244, Issue 5 635-R640, Copyright © 1983 by American Physiological Society

ARTICLES

Alteration of islet neurotransmitter sensitivity following ventromedial hypothalamic lesion

L. A. Campfield and F. J. Smith

Recent studies suggest that alterations in autonomic neural activity may mediate the obese state observed following ventromedial hypothalamic (VMH) lesion. To assess the role of these alterations in the increased glucose responsiveness of the beta-cell observed in this state, we have determined the sensitivity of insulin secretion to norepinephrine or/and acetylcholine in statically incubated pancreatic islets from rats 30-40 days after VMH lesion. In islets from VMH-lesioned rats compared with islets from sham-operated and intact rats, the acetylcholine dose-response curve was shifted down and to the right, indicating a decreased sensitivity, whereas the norepinephrine dose-response curve was translated to the left, indicating an increased sensitivity. The interaction profile, which summarizes combined neurotransmitter exposure on insulin secretion, was shifted in the direction of net inhibition. Thus it was concluded that, following VMH lesion, autonomic neurotransmitter sensitivity of the pancreatic beta-cell was altered. It is suggested that these alterations play a role in the adaptation of the beta-cell to the experimentally induced obese state.


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L. A. Campfield and F. J. Smith
Blood Glucose Dynamics and Control of Meal Initiation: A Pattern Detection and Recognition Theory
Physiol Rev, January 1, 2003; 83(1): 25 - 58.
[Abstract] [Full Text] [PDF]


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