AJP - Regulatory, Integrative and Comparative Physiology, Vol 245, Issue 2 174-R180, Copyright © 1983 by American Physiological Society
Gastric distension and short-term satiety in the rhesus monkey
J. B. Wirth and P. R. McHugh
Fasted rhesus monkeys given access to a solution of glucose (0.5 kcal/ml)
would, within 15 min, consume it to satiety. If, after such a 15-min bout
of consumption, the contents of the stomach were removed via an indwelling
cannula, the monkeys would again consume glucose in a following 15-min
bout. With experiments paired such that gastric contents were either
removed or left in place, the total glucose consumption over four
successive bouts when the stomach was emptied between bouts was twice that
when the contents were undisturbed. Despite this large difference in
consumption, the amount of glucose passing through the pylorus to the
intestine was not different in the two conditions. Similar results were
demonstrated in a nine-bout series of the same design, in a two-bout series
in which gastric contents remaining after the first bout were replaced with
equivolumetric amounts of 0.15 M NaCl, and in a one-bout experiment in
which consumption of glucose followed a 0.15-M NaCl preload equal in volume
to the glucose intake in a single bout the preceding day. Since in the
stomach-empty and the stomach-distended conditions of each experiment the
postpyloric compartments (small intestine, portal, and systemic
circulations) were exposed to identical and physiological amounts of
glucose, the difference in consumption must be ascribed to the distension
of the stomach.
