AJP - Regulatory, Integrative and Comparative Physiology, Vol 245, Issue 5 624-R632, Copyright © 1983 by American Physiological Society
Is the "pool-fraction" paradigm a valid model for assessment of in vivo turnover in non-steady state?
C. Cobelli, A. Ruggeri, G. Toffolo, A. Avogaro and R. Nosadini
Quantification of in vivo turnover of endogenous substances in nonsteady
state is of fundamental importance for understanding a variety of
physiological and clinical metabolic situations. Toward this end, a
pool-fraction model has become a paradigm in the glucose and ketone body
areas. We discuss the basic assumptions on which the pool-fraction model is
based and the criteria on which it has been validated. Specific comments
are then made on its current and potential use for quantifying the
non-steady-state turnover of glucose, ketone bodies, and insulin. We
conclude that the quantitative reliability of predictions provided by the
pool-fraction model is quite poor and that new developments are needed for
quantifying the non-steady-state situation.
