AJP - Regulatory, Integrative and Comparative Physiology, Vol 245, Issue 5 633-R636, Copyright © 1983 by American Physiological Society
Arterial pressure-urinary output relationship in DOCA-saline hypertensive rats
T. Sugai, Y. Nakagawa, K. Takeda and S. Imai
To know the role played by the kidney in the genesis of deoxycorticosterone
acetate (DOCA)-saline hypertension, the arterial pressure-urinary output
(AP-UO) relationship was compared in unanesthetized, unrestrained
uninephrectomized (1-K) control and normal Wistar-Imamichi (W-I) rats
according to the method of Norman et al. [Am. J. Physiol. 234 (Regulatory
Integrative Comp. Physiol. 3): R98-R103, 1973]. The gradient of AP-UO
relationship was slightly decreased in 1-K control rats compared with that
in W-I rats. However, the AP-UO relationship of DOCA-saline hypertensive
rats underwent only a parallel shift to higher blood pressure ranges
compared with that of 1-K control rats. There was no significant change in
the urinary volume, urinary sodium excretion, and urinary osmolarity.
Furthermore, the AP-UO relationship was shifted back to the lower pressure
range under the influence of hydralazine, a preferential renal arteriolar
dilator, suggesting that constriction of the renal artery caused the rise
of the arterial pressure in DOCA-saline hypertensive rats.
