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Am J Physiol Regul Integr Comp Physiol 246: R251-R258, 1984;
0363-6119/84 $5.00
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AJP - Regulatory, Integrative and Comparative Physiology, Vol 246, Issue 2 251-R258, Copyright © 1984 by American Physiological Society

ARTICLES

Discontinuities in phase-resetting experiments

L. Glass and A. T. Winfree

The effects of perturbing an on-going biological oscillation with a single brief stimulus are considered. If the time from some observable event before the stimulus to the next event after the stimulus is plotted as a function of the phase of the stimulus, then there may be discontinuities in this plot. The discontinuities reflect the size of the stimulus and the topological properties of the biological oscillation. The implications for experiments are discussed.




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