AJP - Regulatory, Integrative and Comparative Physiology, Vol 246, Issue 4 624-R632, Copyright © 1984 by American Physiological Society
Renal response of fowl to hypertonic saline infusion into the renal portal system
J. R. Bailey and H. Nishimura
The avian kidney has a dual blood supply: one arising from the renal
arteries and the other from the renal portal system. In anesthetized
pullets (Gallus gallus) two major shunt pathways bypassing the kidney were
occluded to ensure the venous blood returning from the leg suffuses the
peritubular sites before it enters the systemic circulation. Urine was
collected from the ureteral orifices. When 5% NaCl (2.0 ml X kg-1 X h-1)
was infused for 20 min into the renal portal system, urine flow and urinary
NaCl concentrations and excretion rates increased immediately in the
infused side. Infusion of 5% NaCl into the systemic circulation produced no
natriuresis. Infusion of 10% NaCl (4.0 ml X kg-1 X h-1), into either the
systemic or renal portal route, caused a prolonged antidiuresis. Plasma
renin activity (PRA) decreased after portal infusion of 5% NaCl and after
both portal and systemic infusion of 10% NaCl. These results suggest that
1) infusion of hypertonic saline into the renal portal system produces
local renal effects and 2) increases in tubular or peritubular NaCl levels
may suppress PRA.
