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Am J Physiol Regul Integr Comp Physiol 246: R994-R999, 1984;
0363-6119/84 $5.00
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AJP - Regulatory, Integrative and Comparative Physiology, Vol 246, Issue 6 994-R999, Copyright © 1984 by American Physiological Society

ARTICLES

Sleep-promoting effects of endogenous pyrogen (interleukin-1)

J. M. Krueger, J. Walter, C. A. Dinarello, S. M. Wolff and L. Chedid

When infused into the lateral cerebral ventricles of rabbits, human endogenous pyrogen (EP) preparations induced dose-dependent increases in slow-wave sleep concomitant with increasing body temperature. Heating EP to 70 degrees C destroyed its sleep-promoting and pyrogenic activity. Anisomycin (an antipyretic) prevented EP from increasing body temperature without affecting its sleep-promoting activity. Intravenous injection of EP induced fever and transient increases in slow-wave sleep but failed to induce prolonged increases in slow-wave sleep. We conclude that the somnogenic activity of EP is not secondary to its pyrogenic activity.


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