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Am J Physiol Regul Integr Comp Physiol 247: R1017-R1021, 1984;
0363-6119/84 $5.00
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AJP - Regulatory, Integrative and Comparative Physiology, Vol 247, Issue 6 1017-R1021, Copyright © 1984 by American Physiological Society

ARTICLES

Central indomethacin enhances volume-dependent vasopressin release

D. P. Brooks, L. Share, J. T. Crofton and A. Nasjletti

The effect of centrally administered indomethacin on hemorrhage-induced vasopressin release was studied in the morphine-sedated, urethan/chloralose-anesthetized dog. Ventriculocisternal perfusion of indomethacin 1) significantly reduced the amount of prostaglandin E2 in the effluent from the cisterna magna, 2) significantly enhanced the vasopressin response to volume depletion, and led to a greater fall in mean arterial blood pressure during severe hemorrhage. The results suggest that central prostaglandins may have an inhibitory effect on vasopressin secretion during volume depletion.




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