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Am J Physiol Regul Integr Comp Physiol 248: R29-R37, 1985;
0363-6119/85 $5.00
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AJP - Regulatory, Integrative and Comparative Physiology, Vol 248, Issue 1 29-R37, Copyright © 1985 by American Physiological Society

ARTICLES

Osmoregulation and vasopressin secretion during pregnancy in Brattleboro rats

W. M. Barron, J. Durr, B. A. Stamoutsos and M. D. Lindheimer

Osmoregulation during pregnancy was compared in Brattleboro rats completely lacking vasopressin [homozygous (DI)], those with partial deficiency [heterozygous (HZ)], and control Long-Evans (LE) animals. Plasma osmolality (Posmol) was decreased 10-16 mosmol/kg near term in each group, whereas urine osmolality (Uosmol) was similar to that of virgin controls. This was accompanied by significant increments in water turnover similar in HZ and LE and massive in the gravid DI. Chronic vasopressin treatment increased Uosmol less in pregnant DI compared with virgins (P less than 0.001), and urinary prostaglandin E2 was increased in all gravid groups. Captopril per os failed to implicate the renin-angiotensin system in the altered water ingestive behavior of pregnancy. Basal arginine vasopressin pressure (PAVP) was similar in gravid and virgin HZ and LE, whereas the osmotic threshold for AVP secretion was lower in both pregnant groups. Increasing Posmol by dehydration or hypertonic saline led to similar increments in plasma AVP (PAVP) in pregnant and nongravid rats of each group, but sensitivity of the system delta P AVP/delta P osmol was significantly lower in HZ, a difference compatible with the decreased pituitary AVP content in the HZ strain. Data are consistent with decreases in the osmotic thresholds for AVP release (in HZ and LE) and thirst (in DI) and a need for increased AVP secretion during pregnancy.


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J. Joyner, L. A. A. Neves, K. Stovall, C. M. Ferrario, and K. B. Brosnihan
Angiotensin-(1-7) serves as an aquaretic by increasing water intake and diuresis in association with downregulation of aquaporin-1 during pregnancy in rats
Am J Physiol Regulatory Integrative Comp Physiol, March 1, 2008; 294(3): R1073 - R1080.
[Abstract] [Full Text] [PDF]


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