AJP - Regu Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Regul Integr Comp Physiol 248: R68-R71, 1985;
0363-6119/85 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Blair-West, J. R.
Right arrow Articles by Brook, A. H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Blair-West, J. R.
Right arrow Articles by Brook, A. H.

AJP - Regulatory, Integrative and Comparative Physiology, Vol 248, Issue 1 68-R71, Copyright © 1985 by American Physiological Society

ARTICLES

Acute reduction of plasma vasopressin levels by rehydration in sheep

J. R. Blair-West, A. P. Gibson, R. L. Woods and A. H. Brook

Sheep were depleted of water by restricting water intake to 500 ml/day for 7-9 days and were then rehydrated by three treatments: voluntary intake of water, administration of water by tube into the stomach, or voluntary intake of 0.9% NaCl solution (saline). The volumes of fluids drunk within 2-3 min, or administered by tube, were approximately equal to the animal's weight loss. Plasma vasopressin rose from 4.4 +/- 0.6 to 16.8 +/- 1.0 pg/ml during water restriction. After drinking water plasma vasopressin fell from 19.0 +/- 1.9 to 7.5 +/- 0.4 pg/ml (P less than 0.001) in 15 min and gradually fell to 3.2 +/- 0.4 pg/ml over 6 h. Plasma osmolality fell from 302.4 +/- 0.9 to 301.0 +/- 1.1 mosmol/kg (NS) 15 min after water drinking and then gradually fell to subnormal levels. Sheep given water by stomach tube showed a similar decline in plasma osmolality, but the fall in plasma vasopressin was attenuated. The fall in plasma vasopressin in the first 30 min after drinking saline was almost identical with the fall after drinking water, but plasma osmolality was unaltered. Plasma vasopressin fell so rapidly after drinking water or saline as to suggest that the act of drinking caused almost complete inhibition of vasopressin release without a change in plasma osmolality. The results are consistent with earlier evidence that oropharyngeal receptors initiate the inhibition of vasopressin release after drinking.


This article has been cited by other articles:


Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
M. L. Hoffmann, M. DenBleyker, J. C. Smith, and E. M. Stricker
Inhibition of thirst when dehydrated rats drink water or saline
Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2006; 290(5): R1199 - R1207.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
E. M. Stricker and M. L. Hoffmann
Inhibition of vasopressin secretion when dehydrated rats drink water
Am J Physiol Regulatory Integrative Comp Physiol, November 1, 2005; 289(5): R1238 - R1243.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
R. W. Kenefick, C. M. Maresh, L. E. Armstrong, J. W. Castellani, D. Riebe, M. E. Echegaray, and S. A. Kavorous
Plasma vasopressin and aldosterone responses to oral and intravenous saline rehydration
J Appl Physiol, December 1, 2000; 89(6): 2117 - 2122.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
W. Huang, A. F. Sved, and E. M. Stricker
Water ingestion provides an early signal inhibiting osmotically stimulated vasopressin secretion in rats
Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2000; 279(3): R756 - R760.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online