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Am J Physiol Regul Integr Comp Physiol 248: R387-R390, 1985;
0363-6119/85 $5.00
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AJP - Regulatory, Integrative and Comparative Physiology, Vol 248, Issue 3 387-R390, Copyright © 1985 by American Physiological Society

ARTICLES

Is gastric sham feeding really sham feeding?

A. Sclafani and J. W. Nissenbaum

Rats were fitted with gastric cannulas, food deprived, and allowed to drink a sugar solution that drained out of the opened cannula; i.e., the rats sham-fed. Although this procedure is thought to prevent absorption of ingested food, it was found that the sham feeding of a 32% glucose or sucrose solution significantly elevated blood glucose levels. The addition of acarbose, a drug that inhibits the digestion of sucrose, to the 32% sucrose solution blocked the blood glucose rise, as did closing the pylorus with an inflatable pyloric cuff. Neither the drug nor the cuff, however, reduced the amount of sucrose solution consumed. These findings indicate that gastric sham feeding does not necessarily prevent the digestion and absorption of food, although absorption is not essential for the appearance of a vigorous sham-feeding response. Nevertheless the possibility that neural or hormonal feedback from the stomach contributes to the sham-feeding response cannot be excluded, and until this issue is resolved the results of gastric sham-feeding studies should be interpreted with caution.


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B. C. De Jonghe, A. Hajnal, and M. Covasa
Increased oral and decreased intestinal sensitivity to sucrose in obese, prediabetic CCK-A receptor-deficient OLETF rats
Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2005; 288(1): R292 - R300.
[Abstract] [Full Text] [PDF]


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