AJP - Regulatory, Integrative and Comparative Physiology, Vol 248, Issue 5 578-R583, Copyright © 1985 by American Physiological Society
Acute and chronic gastrin-releasing peptide decreases food intake in baboons
D. P. Figlewicz, L. J. Stein, S. C. Woods and D. Porte Jr
Gastrin-releasing peptide (GRP) is a peptide structurally related to
bombesin that appears to be localized to the mammalian gastrointestinal
tract. This study examined the ability of GRP, when administered on either
an acute or chronic basis, to suppress food intake in baboons. When
administered at 8 micrograms/kg iv before a morning meal, GRP significantly
suppressed both food intake and the postprandial rise of plasma glucose and
insulin. GRP at doses of 1, 2, 4, and 8 micrograms/kg stimulated basal
insulin secretion. Chronic administration of GRP (q.o.d. for 11 days) at a
low dose before the A.M. meal resulted in suppression of the A.M. meal and
an initial suppression of total food intake, which recovered before the end
of the treatment period. In conclusion, GRP appears to be effective in
acute suppression of food intake and stimulation of basal insulin secretion
in the nonhuman primate.
