AJP - Regulatory, Integrative and Comparative Physiology, Vol 248, Issue 6 717-R723, Copyright © 1985 by American Physiological Society

ARTICLES

Brown adipose and metabolic features of chronic diet-induced obesity

B. E. Levin, M. Finnegan, J. Triscari and A. C. Sullivan

Half of the 3-mo male Sprague-Dawley rats fed a high-fat (DIO) diet for 5 mo became obese and had increased carcass lipid (106%) and plasma insulin levels (61%), despite 8% less total energy intake than chow-fed controls. Their interscapular brown adipose tissue (IBAT) was 52% heavier with 45% more lipid and larger uni- and multilocular cells. Norepinephrine turnover was normal in their hearts, pancreases, and aortas but undetectable in IBAT where in vitro lipolysis, but not O2 consumption (VO2), was enhanced. Half the rats fed the DIO diet ate 17% fewer calories, gained weight equally to controls, but still had 34% more carcass lipid. Their IBAT was heavier, contained 103% more protein, with no detectable norepinephrine turnover, whereas maximal lipolysis was 73% lower and maximal VO2 was the same or even lower than controls. IBAT VO2 was stimulated by switching 8-mo chow-fed controls to the DIO diet for 7 days (which caused a 480% greater weight gain) but not by switching 8-mo obese rats to chow for 3 days. Therefore metabolic efficiency was increased while BAT VO2 and norepinephrine turnover were unchanged or reduced compared with controls by either chronic obesity or a high-fat diet.

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				D. J. Clegg, S. C. Benoit, J. A. Reed, S. C. Woods, A. Dunn-Meynell, and B. E. Levin Reduced anorexic effects of insulin in obesity-prone rats fed a moderate-fat diet Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2005; 288(4): R981 - R986. [Abstract] [Full Text] [PDF]