AJP - Regulatory, Integrative and Comparative Physiology, Vol 249, Issue 6 667-R671, Copyright © 1985 by American Physiological Society
Endogenous cholecystokinin and intestinal satiety
S. M. Collins, K. L. Conover, P. A. Forsyth and H. P. Weingarten
The role of endogenous cholecystokinin (CCK) as a mediator of intestinal
satiety is examined. We used rats equipped with a chronic gastric fistula
and an indwelling duodenal catheter to assess the effects of direct
duodenal stimulation on sham feeding. To evaluate the contribution of
endogenous CCK to intestinal satiety we used a specific competitive
antagonist of the satiety action of CCK, proglumide. Intraduodenal infusion
of 11 or 5 ml liquid diet suppressed sham feeding. Administration of
proglumide caused a partial reversal of the suppression of feeding produced
by the 11-ml, but not the 5-ml, intraduodenal infusion. Administration of
proglumide alone did not influence sham feeding but completely abolished
the suppression of sham feeding induced by a maximal dose of exogenous CCK.
These results indicate that CCK contributes to intestinal satiety under
specific test conditions only. Moreover, since that component of
suppression reversed by proglumide was small in comparison with the overall
inhibition of eating, these results indicate that factors other than CCK
are important in intestinal satiety.
