AJP - Regulatory, Integrative and Comparative Physiology, Vol 250, Issue 1 96-103, Copyright © 1986 by American Physiological Society
Brain temperature changes coupled to sleep states persist during interleukin 1-enhanced sleep
J. Walter, D. Davenne, S. Shoham, C. A. Dinarello and J. M. Krueger
The effects of human interleukin 1 (IL 1) on the architecture of rabbit
sleep-wake cycles and brain temperature (Tbr) changes coupled to states of
vigilance were examined. Cerebral intraventricular infusion of IL 1 induced
increased slow-wave sleep (SWS), increased electroencephalographic
slow-wave (0.5-4 Hz) amplitudes, and fever. Heat-inactivated IL 1 failed to
elicit these responses. IL 1 also significantly inhibited
rapid-eye-movement (REM) sleep; however, inactivated IL 1 also reduced REM
sleep; thus some of the IL 1-induced REM reduction may be related to the
infusion process. The duration and number of sleep cycles (REM-to-REM
interval) were unaffected by IL 1. Similarly, Tbr changes that normally
occur during the transition from one arousal state to another remained
unchanged after IL 1 infusion, even though rabbits were simultaneously
febrile. We conclude that IL 1 selectively enhances SWS while leaving sleep
cycles and Tbr changes coupled to states of vigilance undisturbed.
