AJP - Regulatory, Integrative and Comparative Physiology, Vol 250, Issue 5 789-R794, Copyright © 1986 by American Physiological Society
Effects of human atrial natriuretic peptide on renal function and vasopressin release
T. Kimura, K. Abe, M. Shoji, K. Tsunoda, K. Matsui, K. Ota, M. Inoue, M. Yasujima and K. Yoshinaga
To assess the effects of atrial natriuretic peptide (ANP) on the renal
function, cardiovascular system, renin-angiotensin-aldosterone system, and
vasopressin release, synthetic human ANP (alpha-hANP) was administered at a
dose of 0.08 microgram X kg-1 X min-1 iv for 40 min into anesthetized dogs
(n = 6). In the control study (n = 6), saline alone was infused. alpha-hANP
brought about a significant increase in renal plasma flow, urinary Na and K
output, urine flow, and osmolar clearance and a significant decrease in
urinary osmolality, free water clearance, and filtration fraction (FF),
with no changes in glomerular filtration rate. Plasma Na concentrations and
osmolality did not change significantly, but plasma K concentrations fell
progressively. Mean arterial blood pressure decreased without any changes
in heart rate. Plasma renin activity (PRA), plasma aldosterone
concentrations (PAC), and plasma vasopressin concentrations did not rise,
but rather PRA and PAC tended to fall during alpha-hANP infusion. In the
control study, there were no changes in these parameters except a
progressive fall in FF and plasma K concentrations. These results indicate
that the alpha-hANP-induced increase in renal blood flow plays an important
role in producing natriuresis, but vasopressin may not be involved in the
process of diuresis.
