AJP - Regulatory, Integrative and Comparative Physiology, Vol 250, Issue 6 1003-R1006, Copyright © 1986 by American Physiological Society

ARTICLES

Control of food intake by fatty acid oxidation

E. Scharrer and W. Langhans

The role of fatty acid oxidation in the control of food intake was studied using mercaptoacetate (MA), an inhibitor of fatty acid oxidation. Food intake, plasma free fatty acids (FFA) and ketone bodies, and blood glucose were measured. Rats were fed either a low-fat (LF, 3.33% fat) or a medium-fat (MF, 18% fat) diet. At the onset of the dark phase of the lighting cycle, MA did not affect food intake in LF rats but increased it 74% in MF rats in comparison to control. Four hours after the injection the effect of MA on food intake disappeared. In the middle of the bright phase of the lighting cycle, MA increased food intake in MF rats approximately 120% up to 6 h postinjection. After MA, plasma FFA concentration was elevated, and plasma 3-hydroxybutyrate concentration was lowered, indicating that fatty acid oxidation had been successfully reduced. MA did not affect blood glucose. These results indicate fatty acid oxidation is involved in the control of food intake, at least when the dietary fat level is relatively high.

This article has been cited by other articles:

				A. Mansouri, S. Aja, T. H. Moran, G. Ronnett, F. P. Kuhajda, M. Arnold, N. Geary, W. Langhans, and M. Leonhardt Intraperitoneal injections of low doses of C75 elicit a behaviorally specific and vagal afferent-independent inhibition of eating in rats Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2008; 295(3): R799 - R805. [Abstract] [Full Text] [PDF]

				S. Matsumura, K. Saitou, T. Miyaki, T. Yoneda, T. Mizushige, A. Eguchi, T. Shibakusa, Y. Manabe, S. Tsuzuki, K. Inoue, et al. Mercaptoacetate inhibition of fatty acid {beta}-oxidation attenuates the oral acceptance of fat in BALB/c mice Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2008; 295(1): R82 - R91. [Abstract] [Full Text] [PDF]

				B. K. Smith Richards, B. N. Belton, B. York, and J. Volaufova Mice bearing Acads mutation display altered postingestive but not 5-s orosensory response to dietary fat Am J Physiol Regulatory Integrative Comp Physiol, February 1, 2004; 286(2): R311 - R319. [Abstract] [Full Text] [PDF]

				V. B Hinderling, P. Schrauwen, W. Langhans, and M. S Westerterp-Plantenga The effect of etomoxir on 24-h substrate oxidation and satiety in humans Am. J. Clinical Nutrition, July 1, 2002; 76(1): 141 - 147. [Abstract] [Full Text] [PDF]

				M. Leonhardt and W. Langhans Hydroxycitrate Has Long-Term Effects on Feeding Behavior, Body Weight Regain and Metabolism after Body Weight Loss in Male Rats J. Nutr., July 1, 2002; 132(7): 1977 - 1982. [Abstract] [Full Text] [PDF]

				S. F. Bernard, E. Mioskowski, and R. Groscolas Blockade of fatty acid oxidation mimics phase II-phase III transition in a fasting bird, the king penguin Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2002; 283(1): R144 - R152. [Abstract] [Full Text] [PDF]

				V. Van Wymelbeke, J. Louis-Sylvestre, and M. Fantino Substrate oxidation and control of food intake in men after a fat-substitute meal compared with meals supplemented with an isoenergetic load of carbohydrate, long-chain triacylglycerols, or medium-chain triacylglycerols Am. J. Clinical Nutrition, November 1, 2001; 74(5): 620 - 630. [Abstract] [Full Text] [PDF]

				S. Boutellier, T. A. Lutz, M. Volkert, and E. Scharrer 2-Mercaptoacetate, an inhibitor of fatty acid oxidation, decreases the membrane potential in rat liver in vivo Am J Physiol Regulatory Integrative Comp Physiol, July 1, 1999; 277(1): R301 - R305. [Abstract] [Full Text] [PDF]

				M. I. Friedman, R. B. Harris, H. Ji, I. Ramirez, and M. G. Tordoff Fatty acid oxidation affects food intake by altering hepatic energy status Am J Physiol Regulatory Integrative Comp Physiol, April 1, 1999; 276(4): R1046 - R1053. [Abstract] [Full Text] [PDF]

				C. C. Horn, A. Addis, and M. I. Friedman Neural substrate for an integrated metabolic control of feeding behavior Am J Physiol Regulatory Integrative Comp Physiol, January 1, 1999; 276(1): R113 - R119. [Abstract] [Full Text] [PDF]

				S. E. Swithers Development of independent ingestive responding to blockade of fatty acid oxidation in rats Am J Physiol Regulatory Integrative Comp Physiol, November 1, 1997; 273(5): R1649 - R1656. [Abstract] [Full Text] [PDF]