AJP - Regulatory, Integrative and Comparative Physiology, Vol 250, Issue 6 1052-R1059, Copyright © 1986 by American Physiological Society
Ablation of subfornical organ does not prevent angiotensin-induced water drinking in sheep
M. J. McKinley, D. A. Denton, R. G. Park and R. S. Weisinger
The subfornical organ (SFO) and surrounding periventricular tissue were
ablated in sheep. Such a lesion did not significantly reduce water drinking
in response to intracarotid, intravenous, or intracerebroventricular
infusions of [Val5]angiotensin II amide (ANG II) but caused reduced intake
of water in response to intracarotid infusion of hypertonic saline. The
dipsogenic response of these sheep to water deprivation for 3 days was
similar to that of normal sheep subjected to water deprivation. Although
the results are not conclusive in excluding the SFO from having a role in
ANG II-induced drinking, they show that there are receptors outside the SFO
sensitive to blood-borne ANG II that are involved in water drinking in
sheep. The results also show that tissue in the SFO or its surroundings may
be involved in drinking caused by acute hypertonicity.
