AJP - Regu Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Regul Integr Comp Physiol 250: R1117-R1122, 1986;
0363-6119/86 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Mangiapane, M. L.
Right arrow Articles by Brody, M. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Mangiapane, M. L.
Right arrow Articles by Brody, M. J.

AJP - Regulatory, Integrative and Comparative Physiology, Vol 250, Issue 6 1117-R1122, Copyright © 1986 by American Physiological Society

ARTICLES

Mechanisms of hemodynamic responses to electrical stimulation of subfornical organ

M. L. Mangiapane and M. J. Brody

The rat subfornical organ (SFO) is involved in the pressor response to circulating angiotensin II, and recent evidence indicates that SFO electrical stimulation also produces a pressor response. In the present experiments we examined the hemodynamic, neural, and humoral mechanisms that underlie the pressor response to electrical stimulation of the SFO. Rats were anesthetized with urethan and instrumented with femoral arterial catheters and with pulsed Doppler flow probes on the superior mesenteric and renal arteries and on the abdominal aorta. Constant-current stimulation, delivered to the SFO via tungsten microelectrodes, resulted in stimulus-locked frequency-dependent pressor responses and vasoconstriction in all vascular beds tested. The stimulation-evoked increases in vascular resistance were greatest in the mesenteric circulation and least in the renal. Movement of the electrode away from the SFO produced significantly smaller responses. Ganglionic blockade abolished the responses to electrical stimulation, whereas vasopressin blockade significantly attenuated the responses. The responses of baroreceptor-denervated rats were qualitatively similar to but approximately double in magnitude of those of normal rats. We conclude that electrical stimulation of the SFO elicits widespread regional vasoconstriction that is most pronounced in the mesenteric circulation. The sympathetic nervous system appears responsible for these effects, but there may be facilitation of the responses by vasopressin.


This article has been cited by other articles:


Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
D. B. Nahey and J. P. Collister
ANG II-induced hypertension and the role of the area postrema during normal and increased dietary salt
Am J Physiol Heart Circ Physiol, January 1, 2007; 292(1): H694 - H700.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online