AJP - Regulatory, Integrative and Comparative Physiology, Vol 251, Issue 1 97-105, Copyright © 1986 by American Physiological Society

ARTICLES

Comparative effects of CCK-8 on feeding, sham feeding, and exocrine pancreatic secretion in rats

R. D. Reidelberger and T. E. Solomon

Cholecystokinin (CCK) is thought to be a hormonal regulator of exocrine pancreatic secretion and is postulated to be a satiety hormone. We compared the dose-response effects of CCK octapeptide (CCK-8) on feeding, sham feeding, and pancreatic secretion to gauge whether the feeding effect might be physiological. Pancreatic responses to intravenous CCK-8 (40, 200, 1,000, or 4,000 pmol . kg-1 . h-1) in fasted unanesthetized rats were compared with effects of CCK-8 (0, 200, 1,000, or 4,000 pmol . kg-1 . h-1) on ingestion of liquid diet in fasted rats with gastric cannulas either closed (normal feeding) or open (sham feeding). Maximal pancreatic amylase output occurred at 200 pmol . kg-1 . h-1 of CCK-8; output declined at higher doses. Food intake was significantly inhibited only at 1,000 and 4,000 pmol . kg-1 . h-1 of CCK-8; the effect was similar when gastric cannulas were closed and open. These results, together with available data on the low postprandial levels of plasma CCK, suggest that circulating levels of CCK normally present after food intake are not sufficient to produce satiety. Furthermore, suppression of feeding by CCK does not appear to be mediated solely by a mechanism that senses gastric distension, because CCK-8 had similar effects in the presence and absence of gastric distension. Whether CCK interacts with other neural or humoral factors to produce satiety by a hormonal mechanism remains to be determined.

This article has been cited by other articles:

				P. K. Chelikani, A. C. Haver, and R. D. Reidelberger Ghrelin Attenuates the Inhibitory Effects of Glucagon-Like Peptide-1 and Peptide YY(3-36) on Food Intake and Gastric Emptying in Rats Diabetes, November 1, 2006; 55(11): 3038 - 3046. [Abstract] [Full Text] [PDF]

				S. Stanley, K. Wynne, B. McGowan, and S. Bloom Hormonal Regulation of Food Intake Physiol Rev, October 1, 2005; 85(4): 1131 - 1158. [Abstract] [Full Text] [PDF]

				S. Eisen, R. J. Phillips, N. Geary, E. A. Baronowsky, T. L. Powley, and G. P. Smith Inhibitory effects on intake of cholecystokinin-8 and cholecystokinin-33 in rats with hepatic proper or common hepatic branch vagal innervation Am J Physiol Regulatory Integrative Comp Physiol, August 1, 2005; 289(2): R456 - R462. [Abstract] [Full Text] [PDF]

				P. K. Chelikani, A. C. Haver, and R. D. Reidelberger Intravenous infusion of glucagon-like peptide-1 potently inhibits food intake, sham feeding, and gastric emptying in rats Am J Physiol Regulatory Integrative Comp Physiol, June 1, 2005; 288(6): R1695 - R1706. [Abstract] [Full Text] [PDF]

				P. K. Chelikani, A. C. Haver, and R. D. Reidelberger Comparison of the inhibitory effects of PYY(3-36) and PYY(1-36) on gastric emptying in rats Am J Physiol Regulatory Integrative Comp Physiol, November 1, 2004; 287(5): R1064 - R1070. [Abstract] [Full Text] [PDF]

				T. Nishi, H. Hara, and F. Tomita Soybean {beta}-Conglycinin Peptone Suppresses Food Intake and Gastric Emptying by Increasing Plasma Cholecystokinin Levels in Rats J. Nutr., February 1, 2003; 133(2): 352 - 357. [Abstract] [Full Text] [PDF]

				R. D. Reidelberger, D. Heimann, L. Kelsey, and M. Hulce Effects of peripheral CCK receptor blockade on feeding responses to duodenal nutrient infusions in rats Am J Physiol Regulatory Integrative Comp Physiol, February 1, 2003; 284(2): R389 - R398. [Abstract] [Full Text] [PDF]

				R. D. Reidelberger, L. Kelsey, D. Heimann, and M. Hulce Effects of peripheral CCK receptor blockade on gastric emptying in rats Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2003; 284(1): R66 - R75. [Abstract] [Full Text] [PDF]

				R. D. Reidelberger, U. Arnelo, L. Granqvist, and J. Permert Comparative effects of amylin and cholecystokinin on food intake and gastric emptying in rats Am J Physiol Regulatory Integrative Comp Physiol, March 1, 2001; 280(3): R605 - R611. [Abstract] [Full Text] [PDF]