AJP - Regulatory, Integrative and Comparative Physiology, Vol 251, Issue 2 314-R319, Copyright © 1986 by American Physiological Society
Hemodynamics of obesity: influence of pattern of adipose tissue cellularity
D. L. Crandall, B. M. Goldstein, F. H. Lizzo, R. A. Gabel and P. Cervoni
Direct quantitation of blood flow with radioactive microspheres in
conscious spontaneously obese rats indicated that the development of
obesity was associated with an elevated cardiac output and stroke volume, a
normotensive blood pressure, and a reduced total peripheral resistance when
directly comparing obese rats with their lean counterparts. Obesity was
also associated with increased blood flow and decreased regional vascular
resistance in a variety of vascular beds, whereas cardiac index and total
peripheral resistance per unit of body weight were similar between groups.
When corrected for tissue weight, unique alterations in flow and resistance
were observed in the adipose tissue. When expressed as resistance per
organ, the greatest relative alterations in vascular resistance with the
development of obesity also occurred in the adipose tissue. Furthermore,
localized adipose tissue expansion through cellular hypertrophy was
consistently associated with a different pattern of blood flow and vascular
resistance than adipose tissue that expanded through both cellular
hypertrophy and hyperplasia, implying an association between depot
cellularity and its hemodynamic profile.
