AJP - Regulatory, Integrative and Comparative Physiology, Vol 252, Issue 1 40-R47, Copyright © 1987 by American Physiological Society

ARTICLES

Na+-H+ exchange and Na+-dependent transport systems in streptozotocin diabetic rat kidneys

S. el-Seifi, J. M. Freiberg, J. Kinsella, L. Cheng and B. Sacktor

The streptozotocin-induced diabetic rat was used to test the hypothesis that Na+-H+ exchange activity in the proximal tubule luminal membrane would be increased in association with renal hypertrophy, altered glomerular hemodynamics, enhanced filtered load and tubular reabsorption of Na+, and stimulated Na+ pump activity in the basolateral membrane, previously reported characteristics of this experimental animal model. Amiloride-sensitive H+ gradient-dependent Na+ uptake and Na+ gradient-dependent H+ flux were increased in brush-border membrane vesicles from the streptozotocin-treated animals. Na+ gradient-dependent uptakes of phosphate, D-glucose, L-proline, and myoinositol were decreased in the drug-induced diabetic animals. These membrane transport alterations were not found when the streptozotocin-diabetic animals were treated with insulin.

This article has been cited by other articles:

				S. Tiwari, S. Riazi, and C. A. Ecelbarger Insulin's impact on renal sodium transport and blood pressure in health, obesity, and diabetes Am J Physiol Renal Physiol, October 1, 2007; 293(4): F974 - F984. [Abstract] [Full Text] [PDF]

				A. Baines and P. Ho Glucose stimulates O2 consumption, NOS, and Na/H exchange in diabetic rat proximal tubules Am J Physiol Renal Physiol, August 1, 2002; 283(2): F286 - F293. [Abstract] [Full Text] [PDF]

				K. Jandeleit-Dahm, K. M. Hannan, C. A. Farrelly, T. J. Allen, J. R. Rumble, R. E. Gilbert, M. E. Cooper, and P. J. Little Diabetes-Induced Vascular Hypertrophy Is Accompanied by Activation of Na+-H+ Exchange and Prevented by Na+-H+ Exchange Inhibition Circ. Res., December 8, 2000; 87(12): 1133 - 1140. [Abstract] [Full Text] [PDF]