| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
AJP - Regulatory, Integrative and Comparative Physiology, Vol 252, Issue 4 699-R709, Copyright © 1987 by American Physiological Society
ARTICLES |
M. K. Sun and P. G. Guyenet
Lumbar sympathetic nerve discharge and unit activity of reticulospinal sympathoexcitatory (SE) neurons located in nucleus paragigantocellularis lateralis (PGCL) were recorded in rats. The sympathoinhibition produced by low-frequency stimulation of vagal afferents was abolished by bilateral microinjections of 20 pmol of bicuculline methiodide (BIC, a GABA-receptor antagonist) into PGCL and was converted into a pressor response by injections of 100 pmol. These BIC injections also inhibited the arterial baroreflex in a dose-dependent manner. In contrast the sympathoexcitation produced by high-frequency stimulation of vagal afferents was selectively blocked by bilateral injections of kynurenic acid (KYN, a Glu-receptor antagonist) into PGCL. Convergence of vagal excitatory, vagal inhibitory, and arterial baroreceptor inputs was detected in all SE neurons recorded. Single-pulse stimulation of vagal afferents produced up to two peaks of excitation of SE neurons, both blocked by iontophoretic applications of KYN and at least one inhibitory period selectively blocked by iontophoresis of BIC. The results emphasize the importance of SE neurons and surrounding area in integrating the brain vasomotor output to spinal preganglionic neurons.
This article has been cited by other articles:
|
|
 |
|
  T. S. Moreira, A. C. Takakura, E. Colombari, G. H. West, and P. G. Guyenet Inhibitory input from slowly adapting lung stretch receptors to retrotrapezoid nucleus chemoreceptors J. Physiol., April 1, 2007; 580(1): 285 - 300. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. H. Coote Landmarks in understanding the central nervous control of the cardiovascular system Exp Physiol, January 1, 2007; 92(1): 3 - 18. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Horiuchi, S. Killinger, and R. A. L. Dampney Contribution to sympathetic vasomotor tone of tonic glutamatergic inputs to neurons in the RVLM Am J Physiol Regulatory Integrative Comp Physiol, December 1, 2004; 287(6): R1335 - R1343. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. D. Stocker, K. J. Keith, and G. M. Toney Acute inhibition of the hypothalamic paraventricular nucleus decreases renal sympathetic nerve activity and arterial blood pressure in water-deprived rats Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2004; 286(4): R719 - R725. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. S. Orer, G. L. Gebber, S. W. Phillips, and S. M. Barman Role of the medullary lateral tegmental field in reflex-mediated sympathoexcitation in cats Am J Physiol Regulatory Integrative Comp Physiol, March 1, 2004; 286(3): R451 - R464. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. R. Potas and R. A. L. Dampney Sympathoinhibitory pathway from caudal midline medulla to RVLM is independent of baroreceptor reflex pathway Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2003; 284(4): R1071 - R1078. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. M. Sartor and A. J. M. Verberne Cholecystokinin selectively affects presympathetic vasomotor neurons and sympathetic vasomotor outflow Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2002; 282(4): R1174 - R1184. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Dean and M. Bago Renal sympathoinhibition mediated by 5-HT1A receptors in the RVLM during severe hemorrhage in rats Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2002; 282(1): R122 - R130. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. M. McAllen, D. Trevaks, and A. M. Allen Analysis of Firing Correlations Between Sympathetic Premotor Neuron Pairs in Anesthetized Cats J Neurophysiol, April 1, 2001; 85(4): 1697 - 1708. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Bago and C. Dean Sympathoinhibition from ventrolateral periaqueductal gray mediated by 5-HT1A receptors in the RVLM Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2001; 280(4): R976 - R984. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. S. Possas, O. U. Lopes, and S. L. Cravo Glutamatergic and GABAergic inputs to the RVL mediate cardiovascular adjustments to noxious stimulation Am J Physiol Regulatory Integrative Comp Physiol, February 1, 2001; 280(2): R434 - R440. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L.-Z. Hong, J.-S. Kuo, M.-H. Yen, and C.-Y. Chai Dorsomedial medulla is more susceptible than rostral ventrolateral medulla to hypoxic insult in cats J Appl Physiol, January 1, 2001; 90(1): 248 - 260. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. D. Potts, A. M. Allen, J. Horiuchi, and R. A. L. Dampney Does angiotensin II have a significant tonic action on cardiovascular neurons in the rostral and caudal VLM? Am J Physiol Regulatory Integrative Comp Physiol, October 1, 2000; 279(4): R1392 - R1402. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Natarajan and S. F. Morrison Sympathoexcitatory CVLM neurons mediate responses to caudal pressor area stimulation Am J Physiol Regulatory Integrative Comp Physiol, August 1, 2000; 279(2): R364 - R374. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Ito, K. Komatsu, K. Tsukamoto, and A. F. Sved Excitatory Amino Acids in the Rostral Ventrolateral Medulla Support Blood Pressure in Spontaneously Hypertensive Rats Hypertension, January 1, 2000; 35(1): 413 - 417. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. C. Araujo, O. U. Lopes, and R. R. Campos Importance of Glycinergic and Glutamatergic Synapses Within the Rostral Ventrolateral Medulla for Blood Pressure Regulation in Conscious Rats Hypertension, October 1, 1999; 34(4): 752 - 755. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Monassier, V. Riehl, J.-P. Lienhard, E. Tibiriça, J. Feldman, and P. Bousquet Effects of Ifenprodil and Baclofen on Exercise-Induced Increase of Myocardial Oxygen Demand in Normotensive Rats J. Pharmacol. Exp. Ther., September 1, 1999; 290(3): 1188 - 1194. [Abstract] [Full Text]
|
|
|
|
|
|
R. R. Randolph, Q. Li, K. S. Curtis, M. J. Sullivan, and J. T. Cunningham Fos expression following isotonic volume expansion of the unanesthetized male rat Am J Physiol Regulatory Integrative Comp Physiol, May 1, 1998; 274(5): R1345 - R1352. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
