AJP - Regu Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Regul Integr Comp Physiol 252: R1152-R1157, 1987;
0363-6119/87 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Bell, R. C.
Right arrow Articles by Lipton, J. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Bell, R. C.
Right arrow Articles by Lipton, J. M.

AJP - Regulatory, Integrative and Comparative Physiology, Vol 252, Issue 6 1152-R1157, Copyright © 1987 by American Physiological Society

ARTICLES

Pulsatile release of antipyretic neuropeptide alpha-MSH from septum of rabbit during fever

R. C. Bell and J. M. Lipton

The effects on fever of central administration of alpha-melanocyte-stimulating hormone (alpha-MSH) and its antiserum, the specific increase in central concentration of alpha-MSH during fever, and related results indicate that this neuropeptide is important to central nervous system (CNS) regulation of the febrile response. The present experiments were designed to establish whether alpha-MSH is released from septal tissue during fever and, if so, in what temporal course relative to the febrile response. alpha-MSH release at localized push-pull perfusion sites within the septum during fever induced by intravenous interlukin-1 occurred in two basic patterns: prolonged or repeated release over sequential 10-min sample periods or a more discrete pulse largely confined to a single 10-min period. The greatest increases in concentration and the greatest number of increases occurred during the chill phase of fever, when temperature was rising rapidly, rather than during the plateau phase. Such episodic release is similar to that known to occur in neuroendocrine and other physiological systems, and it provides further support for a physiological role of alpha-MSH in CNS control of fever.


This article has been cited by other articles:


Home page
 J. Neurosci.Home page
Q.-H. Huang, M. L. Entwistle, J. D. Alvaro, R. S. Duman, V. J. Hruby, and J. B. Tatro
Antipyretic Role of Endogenous Melanocortins Mediated by Central Melanocortin Receptors during Endotoxin-Induced Fever
J. Neurosci., May 1, 1997; 17(9): 3343 - 3351.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online