AJP - Regu AJP: Advances in Physiology Education
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Regul Integr Comp Physiol 253: R719-R725, 1987;
0363-6119/87 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Le Sauter, J.
Right arrow Articles by Geary, N.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Le Sauter, J.
Right arrow Articles by Geary, N.

AJP - Regulatory, Integrative and Comparative Physiology, Vol 253, Issue 5 719-R725, Copyright © 1987 by American Physiological Society

ARTICLES

Pancreatic glucagon and cholecystokinin synergistically inhibit sham feeding in rats

J. Le Sauter and N. Geary
Department of Psychology, Columbia University, New York, New York 10027.

Pancreatic glucagon (PG) elicits satiety in normally feeding rats but fails to inhibit sham feeding in rats with open gastric cannulas. This suggests that a gastric or postgastric food stimulus is necessary for PG's satiating action. To determine whether bombesin or cholecystokinin might provide such a stimulus, sham-feeding rats received simultaneous intraperitoneal injections of 100-800 micrograms/kg of PG and doses of bombesin or cholecystokinin (CCK) that were near the threshold for inhibition of sham feeding. PG and 0.15-to 0.30-micrograms/kg CCK combinations inhibited sham feeding potently (37.6 +/- 7.0 and 62.0 +/- 9.4%, respectively). In contrast, PG and 0.25- to 0.50-microgram/kg bombesin combinations did not significantly affect sham feeding. Behavioral observations indicated that the inhibition of sham feeding by PG plus CCK did not disrupt the normal postprandial satiety sequence of behavior, PG, 400 micrograms/kg, plus 0.15 micrograms/kg of CCK did not inhibit sham drinking in 18-h water-deprived rats. PG, 400 micrograms/kg, plus 0.30 microgram/kg of CCK did inhibit sham drinking, although the effect (34.6 +/- 6.6%) was significantly less than the effect on sham feeding (75.5 +/- 9.7%) in the same rats. These data indicate that CCK is a sufficient food stimulus to permit PG to inhibit sham feeding. Furthermore, this inhibitory effect appears to result from a functional synergism of PG and CCK.


This article has been cited by other articles:


Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
J.-P. Gutzwiller, L. Degen, D. Matzinger, S. Prestin, and C. Beglinger
Interaction between GLP-1 and CCK-33 in inhibiting food intake and appetite in men
Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2004; 287(3): R562 - R567.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
T. H. Moran and E. E. Ladenheim
Context-dependent transduction of within-meal afferent signaling
Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2004; 286(5): R816 - R817.
[Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
T. A. Lutz, A. Estermann, N. Geary, and E. Scharrer
Physiological effect of circulating glucagon on the hepatic membrane potential
Am J Physiol Regulatory Integrative Comp Physiol, November 1, 2001; 281(5): R1540 - R1544.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
M. D. Barrachina, V. Martinez, L. Wang, J. Y. Wei, and Y. Tache
Synergistic interaction between leptin and cholecystokinin to reduce short-term food intake in lean mice
PNAS, September 16, 1997; 94(19): 10455 - 10460.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online