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Am J Physiol Regul Integr Comp Physiol 254: R150-R153, 1988;
0363-6119/88 $5.00
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AJP - Regulatory, Integrative and Comparative Physiology, Vol 254, Issue 1 150-R153, Copyright © 1988 by American Physiological Society

ARTICLES

2,5-anhydro-D-mannitol: a fructose analogue that increases food intake in rats

M. G. Tordoff, R. Rafka, M. J. DiNovi and M. I. Friedman
Monell Chemical Senses Center, Philadelphia, Pennsylvania 19104.

We examined the effects on food intake and plasma fuels of 2,5-anhydro-D-mannitol (2,5-AM; 2-deoxy-D-fructose), a fructose analogue that inhibits hepatocyte gluconeogenesis and glycogenolysis in vitro. 2,5-AM (50-800 mg/kg po) given to rats during the diurnal fast produced a dose-related increase in food intake during the 2 h after administration. A 200-mg/kg dose of 2,5-AM decreased plasma glucose, increased plasma ketone bodies, free fatty acids, and glycerol, and had no effect on triglycerides. Normal and diabetic rats given 2,5-AM (200 mg/kg ip) increased food intake to the same extent. These results suggest that, unlike other substrate analogues that increase food intake, 2,5-AM increases feeding by creating a metabolic state that resembles fasting.


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