AJP - Regulatory, Integrative and Comparative Physiology, Vol 254, Issue 2 204-R211, Copyright © 1988 by American Physiological Society

ARTICLES

Ventricular receptors stimulate vasopressin release during hemorrhage

B. C. Wang, G. Flora-Ginter, R. J. Leadley Jr and K. L. Goetz
Division of Experimental Medicine, St. Luke's Hospital, Kansas City, Missouri 64111.

These experiments were designed to investigate whether a reflex arising from ventricular receptors is capable of stimulating vasopressin secretion during hemorrhage. Three groups of conscious dogs (sham operated, cardiac denervated, and ventricular denervated) were hemorrhaged slowly until 30 ml blood/kg body wt had been removed. Hemorrhage produced comparable decreases in stroke volume, central venous pressure, and left atrial pressure in each group of dogs but produced a different pattern of heart rate response in each group. Plasma vasopressin concentrations before hemorrhage did not differ in the three groups of dogs. In sham-operated dogs plasma vasopressin increased from a control level of 2.4 +/- 0.3 to 6.2 +/- 1.7, 200.0 +/- 65.4, and 991.3 +/- 220.9 pg/ml after 10, 20, and 30 ml/kg of blood had been removed, respectively. In contrast, plasma vasopressin did not increase in either cardiac-denervated or ventricular-denervated dogs after 10 ml/kg of blood had been removed, and the increases in circulating vasopressin after 20 and 30 ml/kg hemorrhage were markedly attenuated by cardiac denervation and by ventricular denervation. The magnitude of the increase in plasma vasopressin in the cardiac-denervated and ventricular-denervated dogs did not differ significantly at comparable levels of hemorrhage. The results are consistent with the possibility that a reflex initiated by ventricular receptors is primarily responsible for stimulating the secretion of vasopressin during hemorrhage in conscious dogs.

This article has been cited by other articles:

				W. H. Cooke, K. L. Ryan, and V. A. Convertino Lower body negative pressure as a model to study progression to acute hemorrhagic shock in humans J Appl Physiol, April 1, 2004; 96(4): 1249 - 1261. [Abstract] [Full Text] [PDF]

				C. L. Holmes, B. M. Patel, J. A. Russell, and K. R. Walley Physiology of Vasopressin Relevant to Management of Septic Shock Chest, September 1, 2001; 120(3): 989 - 1002. [Abstract] [Full Text] [PDF]

				T. N. Thrasher and C. Shifflett Effect of carotid or aortic baroreceptor denervation on arterial pressure during hemorrhage in conscious dogs Am J Physiol Regulatory Integrative Comp Physiol, June 1, 2001; 280(6): R1642 - R1649. [Abstract] [Full Text] [PDF]

				T. N. Thrasher and L. C. Keil Systolic pressure predicts plasma vasopressin responses to hemorrhage and vena caval constriction in dogs Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2000; 279(3): R1035 - R1042. [Abstract] [Full Text] [PDF]

				T. N. Thrasher, H.-G. Chen, and L. C. Keil Arterial baroreceptors control plasma vasopressin responses to graded hypotension in conscious dogs Am J Physiol Regulatory Integrative Comp Physiol, February 1, 2000; 278(2): R469 - R475. [Abstract] [Full Text] [PDF]

				T. N. Thrasher and L. C. Keil Arterial baroreceptors control blood pressure and vasopressin responses to hemorrhage in conscious dogs Am J Physiol Regulatory Integrative Comp Physiol, December 1, 1998; 275(6): R1843 - R1857. [Abstract] [Full Text] [PDF]

				Y. Imai, C.-Y. Kim, J. Hashimoto, N. Minami, M. Munakata, and K. Abe Role of Vasopressin in Neurocardiogenic Responses to Hemorrhage in Conscious Rats Hypertension, January 1, 1996; 27(1): 136 - 143. [Abstract] [Full Text]

				K. Sander-Jensen, J. Marving, N. H. Secher, I.-L. K. Hansen, J. Giese, J. Warberg, and P. Bie Does the Decrease in Heart Rate Prevent a Detrimental Decrease of the End-Systolic Volume during Central Hypovolemia in Man? Angiology, September 1, 1990; 41(9): 687 - 695. [Abstract] [PDF]