AJP - Regu Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Regul Integr Comp Physiol 254: R616-R621, 1988;
0363-6119/88 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Bronson, F. H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Bronson, F. H.

AJP - Regulatory, Integrative and Comparative Physiology, Vol 254, Issue 4 616-R621, Copyright © 1988 by American Physiological Society

ARTICLES

Effect of food manipulation on the GnRH-LH-estradiol axis of young female rats

F. H. Bronson
Department of Zoology, University of Texas, Austin 78712.

Female rats were prevented from growing and developing reproductively by restricting their food intake from the time they reached 80-85 g (27-29 days of age) until they were 2 mo old. A return to ad libitum feeding then typically yielded the pubertal ovulation during the third or fourth dark period. Ad libitum feeding for 48 h increased the frequency of luteinizing hormone (LH) pulsing in ovariectomized females. This treatment also depressed the level of circulating estradiol in ovariectomized females implanted with Silastic capsules. It had no effect on the rate at which estradiol was cleared from the blood in a 1-h test, however, nor did it affect the pool of assayable gonadotropin-releasing hormone (GnRH) in the hypothalamus, the pool of assayable LH in the pituitary, the response of the pituitary to GnRH, or the rate at which LH was cleared from the blood. In toto, the present results suggest that food restriction inhibits pubertal development by acting rather specifically on GnRH secretion via an ovarian steroid-independent pathway. The presumed supplemental role for enhanced negative-feedback sensitivity could not be evaluated because of the aberrant results with encapsulated estradiol.


This article has been cited by other articles:


Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
O. G. Azooz, M. J. G. Farthing, M. O. Savage, and A. B. Ballinger
Delayed puberty and response to testosterone in a rat model of colitis
Am J Physiol Regulatory Integrative Comp Physiol, November 1, 2001; 281(5): R1483 - R1491.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
J. E. Schneider, R. M. Blum, and G. N. Wade
Metabolic control of food intake and estrous cycles in Syrian hamsters. I. Plasma insulin and leptin
Am J Physiol Regulatory Integrative Comp Physiol, February 1, 2000; 278(2): R476 - R485.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
B. Woodside, A. Abizaid, and S. Jafferali
Effect of acute food deprivation on lactational infertility in rats is reduced by leptin administration
Am J Physiol Regulatory Integrative Comp Physiol, June 1, 1998; 274(6): R1653 - R1658.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online