AJP - Regu Watch the video to learn how APS reaches out to developing nations.
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Regul Integr Comp Physiol 254: R659-R662, 1988;
0363-6119/88 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Peronnet, F.
Right arrow Articles by De Champlain, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Peronnet, F.
Right arrow Articles by De Champlain, J.

AJP - Regulatory, Integrative and Comparative Physiology, Vol 254, Issue 4 659-R662, Copyright © 1988 by American Physiological Society

ARTICLES

Epinephrine release from the heart during left stellate ganglion stimulation in dogs

F. Peronnet, R. Nadeau, G. Boudreau, R. Cardinal, D. Lamontagne, N. Yamaguchi and J. De Champlain
Universite de Montreal, Quebec, Canada.

Plasma epinephrine (E) and norepinephrine (NE) concentrations were measured (radioenzymatic assay) in blood samples simultaneously withdrawn from the aorta (Ao) and coronary sinus (CS) on 10 anesthetized dogs immediately before and during a 1-min period of electrical stimulation of the left stellate ganglion (4 V, 4 ms, 10 Hz). Heart rate and systolic blood pressure significantly increased in response to electrical stimulation (152 +/- 8 to 180 +/- 15 beats/min and 128 +/- 12 to 149 +/- 12 mmHg, mean +/- SE; P less than 0.05). Plasma NE concentrations were not significantly different in the Ao and the CS (432 +/- 110 and 319 +/- 67 pg/ml) before the stimulation, whereas a net removal of E was present across the myocardium (Ao, 172 +/- 61; CS, 71 +/- 22 pg/ml). A large NE spillover in the CS was observed during the stimulation (Ao, 1,555 +/- 513; CS, 10,583 +/- 3,753 pg/ml). A significant output of E from the myocardium was also present (Ao, 165 +/- 42; CS, 291 +/- 74 pg/ml) during the stimulation. Determination of NE and E concentrations by high-performance liquid chromatography in five of the dogs confirmed the observation made with the radioenzymatic assay, i.e., a significant uptake (66%) of blood-borne E was present across the myocardium in the control situation (Ao, 320 +/- 97; CS, 110 +/- 23 pg/ml), whereas plasma E concentrations in the CS (280 +/- 61 pg/ml) were 1.5 times the values found in Ao (184 +/- 56 pg/ml) under electrical stimulation. These observations give further support to the hypothesis that endogenous tissue E can act as a cotransmitter of sympathetic fibers.


This article has been cited by other articles:


Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
D. M. Farrell, C.-C. Wei, J. Tallaj, J. L. Ardell, J. A. Armour, G. R. Hageman, W. E. Bradley, and L. J. Dell'Italia
Angiotensin II modulates catecholamine release into interstitial fluid of canine myocardium in vivo
Am J Physiol Heart Circ Physiol, August 1, 2001; 281(2): H813 - H822.
[Abstract] [Full Text] [PDF]

Home page
 HeartHome page
F Bode, U Wiegand, W Raasch, G Richardt, and J Potratz
Differential effects of defibrillation on systemic and cardiac sympathetic activity
Heart, June 1, 1998; 79(6): 560 - 567.
[Abstract] [Full Text]

Home page
 Circ. Res.Home page
J. J. Smolich, H. S. Cox, P. J. Berger, A. M. Walker, G. Eisenhofer, and M. D. Esler
Left Ventricular Norepinephrine and Epinephrine Kinetics at Birth in Lambs
Circ. Res., September 19, 1997; 81(3): 438 - 447.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online