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Am J Physiol Regul Integr Comp Physiol 255: R21-R26, 1988;
0363-6119/88 $5.00
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AJP - Regulatory, Integrative and Comparative Physiology, Vol 255, Issue 1 21-R26, Copyright © 1988 by American Physiological Society

ARTICLES

A comparison of cholecystokinin-induced changes in gastric emptying and feeding in rats

K. L. Conover, S. M. Collins and H. P. Weingarten
Department of Psychology, McMaster University, Hamilton, Ontario, Canada.

We have compared the abilities of the cholecystokinin octapeptide (CCK-8) to delay gastric emptying and to influence feeding under similar experimental conditions in the rat. The effect of CCK-8 on gastric emptying was assessed in 6-h-deprived rats receiving 10-ml intragastric test loads of 0.15 M saline or 15% (wt/vol) sucrose. Analysis of half-emptying times indicated that intraperitoneal administration of CCK-8 in doses of 1.4-22.4 micrograms/kg produced a dose-dependent retardation of emptying of both saline and nutrient. Lower doses of CCK-8, 0.01 and 0.1 micrograms/kg, had no effect on gastric emptying. The effect of CCK-8 on feeding was assessed in normally feeding rats tested under the same experimental conditions used in the gastric emptying studies. Doses of CCK-8 capable of retarding gastric emptying also suppressed eating in a dose-dependent manner. These findings provide necessary correlational support for the hypothesis that the satiety produced by CCK-8 may be mediated by inhibition of gastric emptying. However, a further quantitative analysis of the correspondence of the gastric emptying and feeding effects of CCK-8 suggest that retardation of emptying cannot account entirely for the satiety effect of the peptide.


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Meal pattern analysis to investigate the satiating potential of fat, carbohydrate, and protein in rats
Am J Physiol Regulatory Integrative Comp Physiol, December 1, 1997; 273(6): R1916 - R1922.
[Abstract] [Full Text] [PDF]


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