AJP - Regulatory, Integrative and Comparative Physiology, Vol 255, Issue 2 284-R288, Copyright © 1988 by American Physiological Society

ARTICLES

Effect of starvation and food intake on sympathetic activity

T. Sakaguchi, K. Arase, J. S. Fisler and G. A. Bray
Department of Medicine, School of Medicine, Los Angeles County-University of Southern California Medical Center 90033.

These studies have examined the effect of fasting and nutrient loads on sympathetic firing rate in three groups of rats that develop widely divergent degrees of obesity when eating a high-fat diet. Starvation of Sprague-Dawley rats for 24 or 48 h was associated with a decrease in basal sympathetic activity of nearly 25% in the first 24 h and of slightly greater than 30% in 48 h. This decline in sympathetic activity paralleled the loss of body weight and reduction in adipose tissue mass. After starvation for 48 h, Osborne-Mendel rats, which readily develop obesity when eating a high-fat diet, showed a greater decrease in basal sympathetic activity than did the diet-resistant S 5B/P1 rats. A single liquid 36-kcal intragastric meal was associated with an acute 30% increase in sympathetic firing rate in the overnight-fasted Sprague-Dawley rats. The values 3 h after the meal had returned halfway to normal, and by 6 h they were more than 85% of the way to normal. An intravenous injection of glucose produced a greater rise in sympathetic activity in diet-resistant S 5B/P1 rats than in the diet-sensitive Osborne-Mendel rats. These data are consistent with the hypotheses that sympathetic activity is positively related to nutrient status, that it varies between strains of rats, and that it can be acutely increased by an intragastric meal or by intravenous glucose.

This article has been cited by other articles:

				M. Duclos, E. Timofeeva, C. Michel, and D. Richard Corticosterone-dependent metabolic and neuroendocrine abnormalities in obese Zucker rats in relation to feeding Am J Physiol Endocrinol Metab, January 1, 2005; 288(1): E254 - E266. [Abstract] [Full Text] [PDF]

				K. Nagashima, S. Nakai, K. Matsue, M. Konishi, M. Tanaka, and K. Kanosue Effects of fasting on thermoregulatory processes and the daily oscillations in rats Am J Physiol Regulatory Integrative Comp Physiol, June 1, 2003; 284(6): R1486 - R1493. [Abstract] [Full Text] [PDF]

				C. M. Kotz, C. Wang, A. S. Levine, and C. J. Billington Urocortin in the hypothalamic PVN increases leptin and affects uncoupling proteins-1 and -3 in rats Am J Physiol Regulatory Integrative Comp Physiol, February 1, 2002; 282(2): R546 - R551. [Abstract] [Full Text] [PDF]

				J. M. Overton, T. D. Williams, J. B. Chambers, and M. E. Rashotte Cardiovascular and metabolic responses to fasting and thermoneutrality are conserved in obese Zucker rats Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2001; 280(4): R1007 - R1015. [Abstract] [Full Text] [PDF]

				T. D. Williams, J. B. Chambers, O. L. May, R. P. Henderson, M. E. Rashotte, and J. M. Overton Concurrent reductions in blood pressure and metabolic rate during fasting in the unrestrained SHR Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2000; 278(1): R255 - R262. [Abstract] [Full Text] [PDF]

				K. A. McKnight, H. Rupp, K. S. Dhalla, R. E. Beamish, and N. S. Dhalla Biphasic changes in heart performance with food restriction in rats J Appl Physiol, November 1, 1999; 87(5): 1909 - 1913. [Abstract] [Full Text] [PDF]

				M. Bamshad, C. K. Song, and T. J. Bartness CNS origins of the sympathetic nervous system outflow to brown adipose tissue Am J Physiol Regulatory Integrative Comp Physiol, June 1, 1999; 276(6): R1569 - R1578. [Abstract] [Full Text] [PDF]

				T. J. Bartness and M. Bamshad Innervation of mammalian white adipose tissue: implications for the regulation of total body fat Am J Physiol Regulatory Integrative Comp Physiol, November 1, 1998; 275(5): R1399 - R1411. [Abstract] [Full Text] [PDF]

				S. C. Woods, R. J. Seeley, D. Porte Jr., and M. W. Schwartz Signals That Regulate Food Intake and Energy Homeostasis Science, May 29, 1998; 280(5368): 1378 - 1383. [Abstract] [Full Text]

				M. W. Schwartz and R. J. Seeley Neuroendocrine Responses to Starvation and Weight Loss N. Engl. J. Med., June 19, 1997; 336(25): 1802 - 1811. [Full Text] [PDF]

				R. J. Grekin, A. P. Vollmer, and R. S. Sider Pressor Effects of Portal Venous Oleate Infusion : A Proposed Mechanism for Obesity Hypertension Hypertension, July 1, 1995; 26(1): 193 - 198. [Abstract] [Full Text]