AJP - Regulatory, Integrative and Comparative Physiology, Vol 255, Issue 3 388-R394, Copyright © 1988 by American Physiological Society
Renal nerves and renal responses to volume expansion in conscious monkeys
T. V. Peterson, B. A. Benjamin and N. L. Hurst
Department of Medical Physiology, Texas A&M University College of Medicine, College Station 77843.
Experiments were performed in conscious macaque monkeys to determine the
effect of renal denervation on the diuresis and natriuresis of blood volume
expansion. When the kidneys were innervated, expansion of estimated blood
volume by 20% with 3% dextran in isotonic saline caused increases in urine
flow (V), from 0.28 +/- 0.07 ml/min to a peak response of 1.08 +/- 0.20
ml/min, absolute sodium excretion (UNaV), from 30.0 +/- 11.2 to 99.8 +/-
11.7 mueq/min, and fractional sodium excretion (FENa+), from 1.24 +/- 0.51
to 3.19 +/- 0.56%. The animals then underwent bilateral renal denervation
and were volume expanded a second time 6-13 days postdenervation. Under
this condition, V increased from 0.32 +/- 0.05 to 0.64 +/- 0.08 ml/min,
UNaV, from 22.2 +/- 4.6 to 46.2 +/- 8.0 mueq/min, and FENa+, from 0.91 +/-
0.26 to 1.92 +/- 0.41%, these increases being significantly less than when
the kidneys were innervated. These results demonstrate that the renal
nerves play an important role in the nonhuman primate in mediating
increases in renal excretion during hypervolemia.
