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Am J Physiol Regul Integr Comp Physiol 255: R431-R438, 1988;
0363-6119/88 $5.00
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AJP - Regulatory, Integrative and Comparative Physiology, Vol 255, Issue 3 431-R438, Copyright © 1988 by American Physiological Society

ARTICLES

Cardiovascular and renal responses to stress in borderline hypertensive rat

B. J. Sanders, R. H. Cox and J. E. Lawler
Physiology Program, University of Tennessee, Knoxville 37996.

Wistar-Kyoto (WKY) and borderline hypertensive rats (BHR) were exposed to either a normal or high-sodium chloride (NaCl) diet for 8 wk. Cardiovascular and renal data were collected from arterial and bladder catheters, respectively, in conscious animals during control and stress (aversive classical conditioning) sessions. Results indicated that BHR on a high-NaCl diet exhibited no increase in blood pressure in response to stress compared with BHR on a normal diet. A high-NaCl diet diminished the recovery of blood pressure to base line during stress in WKY compared with normal NaCl controls. Also, a high-NaCl diet and stress interacted in the BHR to decrease sodium excretion and renal plasma flow during stress compared with the control session (3.8 vs. 4.8 mueq.min-1.100 g body wt-1; 3.6 vs. 4.0 ml.min-1. 100 g body wt-1, respectively). Finally, increased dietary NaCl blunted the norepinephrine response to stress in WKY but not in BHR (263 vs. 767 pg/ml). These data suggest that the interaction of genetic and environmental factors are important variables for the development of hypertension.


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