AJP - Regu Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Regul Integr Comp Physiol 255: R794-R798, 1988;
0363-6119/88 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Rawashdeh, N. M.
Right arrow Articles by Ray, N. D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Rawashdeh, N. M.
Right arrow Articles by Ray, N. D.

AJP - Regulatory, Integrative and Comparative Physiology, Vol 255, Issue 5 794-R798, Copyright © 1988 by American Physiological Society

ARTICLES

Differential maturation of beta-adrenoceptor-mediated responses in the lamb fetus

N. M. Rawashdeh, J. C. Rose and N. D. Ray
Department of Physiology, Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, North Carolina 27103.

To study the functional maturity of beta-receptor-mediated responses, seven chronically catheterized lamb fetuses, 93-107 days of gestation, and seven fetuses, 116-134 days of gestation, received intravenous randomly sequenced infusions of isoproterenol (ISO) 0.03, 0.06, and 0.125 micrograms.kg-1.min-1 for 10 min separated by 45-min intervals or two saline infusions followed by 0.125 micrograms.kg-1.min-1 ISO after treatment with 0.5 mg/kg propranolol (PRO). Each fetus received the two treatments 24-48 h apart. In immature fetuses, plasma renin activity (PRA) of 2.0 +/- 0.7 ng.ml-1.h-1 did not change with either protocol. In mature fetuses, PRA of 7.5 +/- 2.5 ng.ml-1.h-1 increased two- to three-fold after the infusion of the highest two doses of ISO (P less than 0.003). Propranolol blocked this response. No significant changes were observed after the infusions of the lowest dose of ISO or saline. Both groups showed significant heart rate increases with all doses of ISO. Propranolol injection decreased heart rate significantly and blocked responses to ISO. We conclude that although a cardiac beta-receptor-mediated response is present by 93 days of gestation in the lamb fetus, a renal beta-receptor-mediated response, renin secretion, is absent.


This article has been cited by other articles:


Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
H. L. Mertz, J. Liu, N. K. Valego, S. P. Stallings, J. P. Figueroa, and J. C. Rose
Inhibition of cyclooxygenase-2: effects on renin secretion and expression in fetal lambs
Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2003; 284(4): R1012 - R1018.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
J. Wang and J. C. Rose
Developmental changes in renal renin mRNA half-life and responses to stimulation in fetal lambs
Am J Physiol Regulatory Integrative Comp Physiol, October 1, 1999; 277(4): R1130 - R1135.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
C. E. Giammattei, J. W. Strandhoy, and J. C. Rose
Regulation of in vitro renin secretion by ANG II feedback manipulation in vivo in the ovine fetus
Am J Physiol Regulatory Integrative Comp Physiol, October 1, 1999; 277(4): R1230 - R1238.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online