AJP - Regulatory, Integrative and Comparative Physiology, Vol 256, Issue 1 161-R168, Copyright © 1989 by American Physiological Society

ARTICLES

Sympathoadrenal influence on glucose, FFA, and insulin levels in exercising rats

A. J. Scheurink, A. B. Steffens, H. Bouritius, G. H. Dreteler, R. Bruntink, R. Remie and J. Zaagsma
Department of Animal Physiology, State University of Groningen, Haren, The Netherlands.

The effects of sympathoadrenal manipulations on the exercise-induced alterations in blood glucose, plasma free fatty acids (FFA), and insulin were investigated in intact and adrenodemedullated rats. Exercise consisted of strenuous swimming against a countercurrent for 15 min. Before, during, and after swimming, blood samples were taken through a permanent heart catheter. Adrenodemedullation (Adm) markedly reduced the exercise-induced increase in both glucose and FFA. This effect was counteracted by intravenous infusion of epinephrine (E, 20 ng/min). Intravenous infusion of 50 ng E/min into Adm rats caused an exaggerated increase in glucose. In two additional experiments 1) specific adrenoceptor agonists and antagonists were administered to exercising intact and Adm rats, and 2) E or norepinephrine (NE; 20 ng/min) was infused into intact resting rats. The results suggest that E from the adrenal medulla directly affects glucose and insulin but not FFA concentrations in the blood. NE released from peripheral sympathetic nerve endings probably acts in two different ways: as neurotransmitter on liver and pancreas and as a hormone on adipose tissue.

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