AJP - Regu Information on EB 2010
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Regul Integr Comp Physiol 256: R231-R235, 1989;
0363-6119/89 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Machado, B. H.
Right arrow Articles by Brody, M. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Machado, B. H.
Right arrow Articles by Brody, M. J.

AJP - Regulatory, Integrative and Comparative Physiology, Vol 256, Issue 1 231-R235, Copyright © 1989 by American Physiological Society

ARTICLES

Contribution of neurogenic mechanisms to control of intrinsic heart rate

B. H. Machado and M. J. Brody
Department of Pharmacology, College of Medicine, University of Iowa, Iowa City 52242.

Altered autonomic tone as well as humoral factors can change the intrinsic rate of the cardiac pacemaker. To study the relationships of neurogenic and humoral factors on intrinsic heart rate (IHR) we used sinoaortic deafferentation (SAD) to increase sympathetic activity, lesion of nucleus ambiguus to reduce central parasympathetic activity, and one-kidney, one-clip (1K1C) renal hypertension to transiently increase the activity of the renin-angiotensin system and the combination of 1K1C hypertension with SAD. In conscious rats, IHR was determined using combined blockade with atropine and propranolol. Rats with 1K1C hypertension (7th day) showed increased mean arterial pressure (MAP), heart rate (HR), and IHR. Rats with SAD (4th day) demonstrated increased MAP and HR, but in contrast, had decreased IHR. Lesion of nucleus ambiguus increased HR and decreased IHR. When 1K1C hypertension was combined with SAD an additional increase in MAP and HR occurred, whereas IHR was reduced compared with renal hypertension alone. These data suggest that IHR is influenced greatly by autonomic tone and that the tachycardia in renal hypertension is linked to increased IHR that is dependent on integrity of the baroreflex.


This article has been cited by other articles:


Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
S. J. Swoap, C. Li, J. Wess, A. D. Parsons, T. D. Williams, and J. M. Overton
Vagal tone dominates autonomic control of mouse heart rate at thermoneutrality
Am J Physiol Heart Circ Physiol, April 1, 2008; 294(4): H1581 - H1588.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
S. L. Bealer
Central control of cardiac baroreflex responses during peripheral hyperosmolality
Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2000; 278(5): R1157 - R1163.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online