AJP - Regu Email Content Delivery
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Regul Integr Comp Physiol 256: R332-R338, 1989;
0363-6119/89 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Gardiner, S. M.
Right arrow Articles by Bennett, T.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Gardiner, S. M.
Right arrow Articles by Bennett, T.

AJP - Regulatory, Integrative and Comparative Physiology, Vol 256, Issue 2 332-R338, Copyright © 1989 by American Physiological Society

ARTICLES

Regional hemodynamic effects of calcitonin gene-related peptide

S. M. Gardiner, A. M. Compton and T. Bennett
Department of Physiology and Pharmacology, Medical School, Queen's Medical Centre, Nottingham, United Kingdom.

Cardiovascular responses to infusions of rat alpha-calcitonin gene-related peptide (CGRP; 0.06, 0.6, 6.0 nmol/h) or rat alpha-atrial natriuretic peptide (ANP; 3.7 nmol/h) were measured in conscious rats. During infusion of the low dose of CGRP, when mean arterial pressure (MAP) was little affected, there were reductions in common carotid, renal, mesenteric, and hindquarter vascular resistances (the magnitude of the responses in the same descending order). However, only flow in the common carotid vessels was increased above base line. After infusion, there was a hindquarter vasoconstriction. During infusion of the higher doses of CGRP, there were dose-related decreases in MAP and increases in heart rate associated with (hyperemic) hindquarter vasodilatations and mesenteric vasoconstrictions. The common carotid vasodilatation peaked with the intermediate dose of CGRP; the changes in renal vascular resistance were not dose related. After infusion of the high dose of CGRP there were persistent (at least 60 min) common carotid and hindquarter vasodilatations and mesenteric vasoconstriction, with a transient overshoot in renal vascular resistance. Infusions of CGRP and ANP matched for their effects on MAP had similar influences on mesenteric hemodynamics, but all other variables were affected differently.


This article has been cited by other articles:


Home page
 Physiol. Rev.Home page
S. D. Brain and A. D. Grant
Vascular Actions of Calcitonin Gene-Related Peptide and Adrenomedullin
Physiol Rev, July 1, 2004; 84(3): 903 - 934.
[Abstract] [Full Text] [PDF]

Home page
 Anesth. Analg.Home page
D. Yoshikawa, M. Kuroda, H. Tsukagoshi, K.-i. Takahashi, S. Saito, K. Nishikawa, and F. Goto
The Effects of Volatile Anesthetics on Nonadrenergic, Noncholinergic Depressor Responses in Rats
Anesth. Analg., January 1, 2003; 96(1): 125 - 131.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online