AJP - Regulatory, Integrative and Comparative Physiology, Vol 256, Issue 3 646-R652, Copyright © 1989 by American Physiological Society

ARTICLES

Evidence for a physiological role for CCK in the regulation of food intake in mice

A. J. Silver, J. F. Flood, A. M. Song and J. E. Morley
Geriatric Research, Education, and Clinical Center, Sepulveda Veterans Administration Medical Center 91343.

The effects of L-364,718, a cholecystokinin receptor antagonist, on cholecystokinin octapeptide-induced inhibition of food, and its effect on food intake when given alone, were studied in mice using several different feeding paradigms. In all studies, L-364,718 (100 micrograms/kg, 1.0 mg/kg) reversed the ability of cholecystokinin octapeptide to decrease food intake. L-364,718 enhanced food consumption compared with controls in nonfasted mice (100 microgram/kg) and in prefed mice (50, 100, 250 micrograms/kg). The number of reinforcements, using a lever press, was also enhanced by L-364,718 (100 micrograms/kg) compared with control. In other paradigms, L-364,718 failed to enhance food intake. These results are compatible with the suggestion that cholecystokinin may play a physiological role in the regulation of food intake.

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